Natpro Progesterone Cream Review: Side Effects 2025

Natpro Progesterone Cream is a natural bioidentical progesterone supplement designed to support hormonal balance for women dealing with symptoms of menopause, premenstrual syndrome (PMS), polycystic ovary syndrome (PCOS), or other hormonal imbalances. The key ingredient, natural progesterone, is bioidentical, meaning it mimics the progesterone naturally produced by the body. It is delivered through a transdermal cream that is absorbed through the skin, allowing it to bypass the digestive system and enter the bloodstream directly.

In this review, I will cover how Natpro Progesterone Cream works, its ingredients, benefits, potential side effects, and whether it is a good choice for women looking to support hormonal health naturally.

What is Natpro Progesterone Cream?

Natpro is marketed as a natural progesterone cream intended to supplement the body’s natural production of progesterone, particularly during times of hormonal imbalance such as menopause, perimenopause, or in cases of low progesterone levels. The cream contains 2,000 mg of bioidentical progesterone per 2 oz. tube, with a standard dose of 20 mg per application.

Progesterone is a vital hormone that plays a key role in regulating menstrual cycles, fertility, and overall hormonal balance. As women approach menopause, progesterone levels often decline, leading to symptoms such as hot flashes, mood swings, irregular periods, and sleep disturbances. Natpro aims to restore balance by replenishing progesterone levels through transdermal absorption.

How Does Natpro Progesterone Cream Work?

Natpro works by delivering bioidentical progesterone through the skin, which is absorbed into the bloodstream and helps maintain healthy progesterone levels. This can help counteract the effects of estrogen dominance and alleviate symptoms related to hormonal imbalances.

1. Hormonal Balance: By increasing progesterone levels, Natpro can help balance out excess estrogen, which is a common issue in women going through menopause or those with PMS or PCOS. This balance can reduce symptoms such as mood swings, anxiety, and irritability.
2. Menopause Symptom Relief: Progesterone cream is commonly used to alleviate menopausal symptoms such as hot flashes, night sweats, and sleep disturbances. Restoring progesterone can also improve bone density and skin elasticity, making it a popular choice for postmenopausal women.
3. Fertility Support: Progesterone is crucial for maintaining pregnancy, and Natpro can be used to support fertility in women who have low progesterone levels that may be impacting their ability to conceive.

Key Ingredients in Natpro Progesterone Cream

1. Bioidentical Progesterone: The main active ingredient is bioidentical progesterone, which is structurally identical to the hormone produced naturally in the body. It’s derived from wild yams, which are chemically processed to produce natural progesterone.
2. Aloe Vera and Vitamin E: These ingredients are included to nourish the skin and help with the absorption of the cream. Aloe Vera has moisturizing properties, while Vitamin E supports skin health and antioxidant protection.

Potential Benefits of Natpro Progesterone Cream

1. Supports Hormonal Balance: Natpro can help relieve symptoms of estrogen dominance and promote a healthy progesterone to estrogen ratio, which is vital for women dealing with menstrual irregularities and hormonal imbalances.
2. Alleviates Menopausal Symptoms: By supplementing declining progesterone levels, Natpro can reduce hot flashes, night sweats, and other uncomfortable menopausal symptoms.
3. Improves Sleep and Mood: Progesterone has a calming effect on the brain and can help reduce anxiety, insomnia, and mood swings commonly associated with hormonal changes.
4. Non-Synthetic: As a bioidentical progesterone product, Natpro is natural, making it a more attractive option for those seeking alternatives to synthetic hormones found in hormone replacement therapy (HRT).

Potential Side Effects

While bioidentical progesterone is generally well-tolerated, some individuals may experience mild side effects, particularly if they are sensitive to hormone changes or use too much cream. Common side effects include:

• Breast tenderness or swelling.
• Headaches.
• Mood changes, such as irritability or anxiety, especially when adjusting to the hormone supplementation.
• Skin irritation at the application site.

It is essential to follow the recommended dosage and consult a healthcare provider before starting Natpro, especially if you have underlying health conditions or are using other hormone-related medications​(Murad Skincare).

Who Should Consider Using Natpro Progesterone Cream?

Natpro is best suited for women who:

• Are experiencing hormonal imbalances due to menopause, perimenopause, or PMS.
• Want to avoid synthetic hormone therapies and are looking for a natural, bioidentical alternative.
• Have been diagnosed with low progesterone levels that may be affecting fertility or menstrual cycles.
• Are looking for a transdermal progesterone cream that bypasses the digestive system for more efficient absorption.

Final Thoughts: Is Natpro Progesterone Cream Worth It?

From a medical perspective, Natpro Progesterone Cream offers a safe and effective way to supplement progesterone for women dealing with hormonal imbalances, particularly during menopause or premenstrual issues. The use of bioidentical hormones makes it an appealing option for those looking for a natural alternative to HRT, and its ability to alleviate symptoms such as hot flashes, mood swings, and sleep disturbances can be highly beneficial.

However, it’s crucial to consult a healthcare provider before beginning any hormonal supplementation, especially for women with a history of hormone-related conditions or those currently undergoing hormone therapy. The cream is generally well-tolerated, but proper usage and monitoring are key to minimizing side effects.

For women seeking hormonal balance and relief from menopausal symptoms, Natpro is a product worth considering.